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Sântana is a town in north-western Romania, in the county of Arad. The town is situated in the northern part of the Aradului Plateau, at a 29 km distance from the county capital (Arad). It is an urban centre established recently, it adheres also the rural locality called Caporal Alexa.

The first documentary record of the locality under the name Sântana goes back to the year 1828. The settlement is the result of the continuous development of Comlăuș, a locality mentioned already in 1334. Caporal Alexa was mentioned in 1334 when it was called Kerecton.

Although the economy of the town is prevalent agricultural, the secondary and tertiary economic sectors have also developed recently. Sântana is an important centre of vineyards.

Its status as a significant road and railway junction can be used also for the promotion and improvement of the tourism. The specific architecture, the historical and architectural monuments as the "Convictului" building, the copyhold house and the fortifications called "Cetatea veche" are only a few of the locality's touristic sights.